Suarez had keyhole surgery on his left knee just three weeks ago and although he appears to be recovering well, coach Oscar Tabarez is unlikely to risk him against what promises to be the weakest team in the group.
The Liverpool striker was sensational in the English Premier League last season, scoring 31 goals in 33 appearances, way more than any other player.
But although his absence is a concern for the Uruguayans, they are blessed with an abundance of attacking riches.