Striker Edinson Cavani and defender Jorge Fucile were both dismissed in the second half of a bad-tempered encounter on Wednesday in Santiago.
Cavani’s dismissal looked particularly harsh as he responded relatively mildly to provocation from Chile fullback Gonzala Jara.
After the dismissal of Fucile near the end of the game, the Uruguayan players lost their tempers, shoved the linesman and came close to blows with some of the Chilean players.